The Role Of Fatty Acids In Insulin Resistance

New research into insulin resistance reveals that not all organs and receptor sites react in the same ways. This further complicates the problem. How do we ensure optimal levels are achieved and maintained?

This new research by Barry Sears Email author  and Mary Perry peels away another secret of the body’s endless complexity.

The human body has developed an extraordinary number of systems to maintain stable blood glucose and to avoid broad swings in its level. These systems include hormones that are directly or indirectly generated by the diet.

These hormones sense dietary nutrients and send appropriate neural signals to the brain (specifically the hypothalamus) to orchestrate fuel usage for either oxidation into energy or long-term storage. The central hormone involved in this metabolic communication system is insulin.

Insulin resistance is a multi-faceted disruption of the communication between insulin and the interior of a target cell. The underlying cause of insulin resistance appears to be inflammation that can either be increased or decreased by the fatty acid composition of the diet. However, the molecular basis for insulin resistance can be quite different in various organs.
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